CGNPS is a molecular dynamics simulation package for simulating a coarse- grained model of the mammalian nuclear periphery. CGNPS is intended to enable a researcher to study nuclear mechanotransduction in three stages: (a) assemble the nuclear periphery structure with bioimaging and bioinformatics data, (b) tune interaction parameters for calibration with biomechanical data, and (c) build and run custom in silico experiments to study nuclear mechanotransduction. Link to project website.

CGNS is being developed for simulating a coarse-grained model of the mammalian nucleus. So far, the planar NE in CGNPS is converted to spherical shape, resulting in a NE vesicle. Next, chromatin would be added back. Link to project website.